MAPT and Mental deterioration: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, marked by progressive cognitive decline and the accumulation of neuropathological hallmarks, including extracellular β-amyloid (Aβ) plaques, intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau, and a sustained neuroinflammatory response (1).