GSDMD and Sepsis: Furthermore, the costimulatory molecule GITR has been shown to promote immunosuppression in sepsis by enhancing NLRP3 inflammasome-mediated macrophage pyroptosis (42), whereas inhibition of the TMEM173-GSDMD-F3 pathway improves septic mice survival by blocking disseminated intravascular coagulation (DIC) (43), providing further evidence for pyroptosis in sepsis immunosuppression.