Postmortem analyses reveal profound splenic T cell depletion with concurrent PD-L1 upregulation in sepsis fatalities compared to non-infectious mortality controls (24), which may be attributed to the increased levels of cytochrome C, Bim, caspase-3, caspase-8, and caspase-9, while decreased expression of B-cell lymphoma/leukemia-2 (Bcl-2) (25). This evidence concerns the gene CD274 and Sepsis.