By using Cytoscape software (Version: 3.10.2) in conjunction with MCC algorithms of the CytoHubba plugin, we identified the top 5 hub genes within the network (IL1B, NFKB1, MAP2K1, PRKACA, and HSP90AA1), suggesting that these genes are potential targets for EMPA and MET in heart failure therapy (Figure 6C). Here, HSP90AA1 is linked to heart failure.