PRKACA and heart failure: By using Cytoscape software (Version: 3.10.2) in conjunction with MCC algorithms of the CytoHubba plugin, we identified the top 5 hub genes within the network (IL1B, NFKB1, MAP2K1, PRKACA, and HSP90AA1), suggesting that these genes are potential targets for EMPA and MET in heart failure therapy (Figure 6C).