Genes were chosen if they were known to interact with EMPA and MET and had documented expression in the heart, particularly those that regulate myocardial fibrosis and hypertrophy, which are hallmark features of HFpEF.Through Venn diagram analysis, we discovered 40 overlapping targets (Figure 6A), which may be effective targets for EMPA and MET in the treatment of HFpEF. The gene discussed is MET; the disease is Myocardial fibrosis.