In addition to inactivating the oncogene pRb in virus‐infected cells, alterations in other signaling pathways are equally important for the transformation of HPV E7 oncogene‐transduced cells.[33] PI3K/AKT/mTOR signaling pathway is frequently amplified in HPV‐induced cancers and plays a very important role in the oncogenic process.[34] We found that BAG2 knockdown activated the AKT/mTOR signaling pathway, which was inhibited by STING overexpression or HPV E7 silencing (Figure S10A,B, Supporting Information). Here, RB1 is linked to cancer.