Furthermore, the STAT3 inhibitor WP1066 could inhibit the phosphorylation of STAT3, reduce the expression of PD‐L1, impede the PD‐1/PD‐L1 binding, restore cytotoxic T‐lymphocyte (CTL) function, and regulate the immunosuppressive microenvironment.[34, 35] The therapeutic efficacy of TVW‐based tumor photodynamic immunotherapy was expected to be improved by simultaneous modulation of tumor hypoxia and immunosuppressive landscape. The gene discussed is CD274; the disease is neoplasm.