Mutant TDP-43 accounts for in 4% of fALS and 1% of sALS cases, while pathological TDP-43 can be detected in the brain or spinal cord in over 95% of ALS cases and over 40% of frontotemporal dementia cases (Prasad et al., 2019). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.