A previous study demonstrated that the depletion of TDP-43 leads to the decreased binding of TDP-43 to STMN2 pre-mRNA and the concurrent production of nonfunctional stathmin-2 mRNA, leading to reduced levels of functional stathmin-2, which seemingly contributes to the pathogenesis of ALS (Elden et al., 2010; Pottier et al., 2019). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.