Since the discovery of the first ALS-related gene mutation in SOD1 three decades ago, the exploration of ALS-related mutated genes has been in full bloom, with TARDBP, FUS, C9orf72, NEK1, CCNF, and VCP among those identified (Elmansy et al., 2023). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.