As direct viral invasion of the CNS or an exaggerated immune response in severe dengue cases may generate dengue-associated encephalitis, with symptoms as seizures, altered mental status, headaches, and even coma, there can be a role for the purinergic microglial receptor P2Y12, as it has been described that microglia protect from viral replication as well, since its pharmacological depletion by clodronate liposomes in DENV infection reduced antiviral cytokines production, leading to increased brain viral titer, worsen clinical scores and elevated mortality (Tsai et al., 2016). This evidence concerns the gene P2RY12 and dengue disease.