Purinergic signaling plays a crucial role in this process, as purine mediators such as ATP may be released, stimulating the P2X7 receptor and feeding the calcium influx, the cell death mechanisms, and even the release of neurotransmitters and proconvulsive cytokines, boosting epilepsy gravity (Méndez et al., 2020). This evidence concerns the gene P2RX7 and epilepsy.