Recent studies in multiple animal models of AD showed that TREM2 deficiency affects the clustering of microglia around the plaques, making them more diffuse and surrounded by more neuritic damage, suggesting that the microglial response to plaques is dependent on TREM2 expression (Jay et al. 2015; Puntambekar et al. 2022; Takahashi et al. 2005; Ulrich et al. 2014; Wang et al. 2015; Wang et al. 2016; Wood et al. 2022). Here, TREM2 is linked to Alzheimer disease.