Conversely to what is observed for the amyloid seeding activity ratio, these results showed that old‐Tg mice homogenates were able to seed a higher tau pathology in the ipsilateral side of 3xTg‐AD mice than the human AD samples, as calculated for AT8 (62% ± 17.26%, unpaired t‐test, t(9) = 3.238, p = 0.0102, Figure 2G), PHF1 (58% ± 11.68%, unpaired t‐test, t(10) = 5.008, p = 0.0005, Figure 2H) and MC1 (34% ± 11.62%, unpaired t‐test, t(9) = 3.878, p = 0.0037, Figure 2I). This evidence concerns the gene PHF1 and Alzheimer disease.