AIF1 and Alzheimer disease: As shown in Figure 4B, Iba1‐microglia were abundant in close contact with plaques in 3xTg‐AD mice injected with PBS (Figure 4B1) or the human Aβ seeds (Figure 4B2); however, in those mice inoculated with old‐Tg mice seeds, periplaque microglia were almost absent (Figure 4B3).