A similar effect may also occur with tau pathology (Asai et al. 2015; Chen et al. 2024; Gratuze et al. 2021; Hopp et al. 2018; Leyns et al. 2019; Maphis et al. 2015; Wang et al. 2022) and interestingly, it has been recently reported that microglial activation anatomically correlates with tau pathology Braak staging in AD brains (Pascoal et al. 2021). Here, MAPT is linked to Alzheimer disease.