H2BC15 and major depressive disorder: We identified three genes (BTN3A2, HIST1H2BN and HIST1H4L) that are associated with both SA and major psychiatric disorders, such as MDD (Yang et al. 2021), schizophrenia (SCZ) (Li et al. 2022a, 2022b), bipolar disorder and autism spectrum disorder (Yulu Wu et al. 2020), suggesting a potential genetic overlap and pleiotropic effects across these conditions.