OTC and systemic inflammatory response syndrome: In 2009, eighteen hours after a hepatic artery infusion of a recombinant human adenovirus type-5 carrying the ornithine transcarbamylase cDNA at a dose of 6 × 1011 particles/kg, an 18 year old patient with partial ornithine transcarbamylase deficiency developed systemic inflammatory response syndrome, which led to multi-organ failure and his demise [90].