In HER-2 positive breast cancer cells (SKBR3), Tityus discrepans venom demonstrated significant efficacy in modulating apoptosis-related markers, upregulating pro-apoptotic proteins such as Fas ligand (FasL), and downregulating anti-apoptotic markers like Bcl-2, effectively inducing apoptosis in SKBR3 cells. This evidence concerns the gene BCL2 and breast cancer.