Triple-negative breast cancer cells, including MDA-MB-231 and F3II, were sensitive to venoms from Rhopalurus junceus, Androctonus bicolor, Androctonus crassicauda, and Leiurus quinquestriatus. These venoms modulated gene expression by upregulating pro-apoptotic markers such as Bax and Caspase-3 while downregulating anti-apoptotic markers like Bcl-2, strongly promoting apoptosis in these highly aggressive and treatment-resistant breast cancer cells. The gene discussed is BAX; the disease is breast cancer.