IL1B and keratoconus: Similarly, Shetty et al. [24] demonstrated substantially increased tear levels of TNF-α (806 ± 168 pg/mL vs. 96 ± 49 pg/mL, p = 0.007) and IL-1β (2474 ± 486 pg/mL vs. 24 ± 21 pg/mL, p = 0.001) in KC cases than controls.