When stratifying the KC patients by disease severity, we observed a counterintuitive trend in IL-6 levels, with concentrations progressively decreasing with increasing disease severity (9.0240 ± 7.6352 ng/mL in mild, 7.0017 ± 5.8027 ng/mL in moderate, and 6.342 ± 3.3310 ng/mL in severe KC), although this pattern failed to reach statistical significance (p = 0.593). Here, IL6 is linked to keratoconus.