Giridharan et al., 2020 [83], found that clozapine decreases IL-1β and IL-17 concentrations, whereas Yuan et al., 2022 [20], observed that clozapine upregulates IL-17 and TNF-α and downregulates IL-1β in patients with schizophrenia undergoing constant treatment. The gene discussed is TNF; the disease is schizophrenia.