In addition, there is evidence suggesting that obesity is associated with lymph node metastases after RP, owing to the deranged prostatic microenvironment and cellular DNA caused by inflammatory factors (IL-6, IL-8, VEGF, leptin) and altered insulin-IGF-1 axis [38,39,40]. The gene discussed is INS; the disease is metastatic malignant neoplasm in the lymph nodes.