Based on current evidence, the occurrence of postpartum glucose alterations after GDM is linked to a range of predictors, involving both maternal risk factors, including advanced age, obesity, family history of T2D, non-Caucasian ethnicity, and pregnancy-specific factors, such as high levels of glycemia at OGTT, increased HbA1c, insulin use, multiparity, hypertensive disease, and preterm delivery [7]. The gene discussed is INS; the disease is gestational diabetes.