IL6 and neoplasm: Persistent chronic inflammation leads to regional changes in the tumor immune microenvironment (TIME) and to systemic effects like the increased production of cytokines (interleukin-6 (IL-6)), interleukin-1 (IL-1), the macrophage colony-stimulating factor, an impaired cellular division rate, DNA damage, an increased cell apoptosis and angiogenesis [16,17,18].