AD is a chronic, relapsing eczematous skin disease with a complex presentation, driven by epidermal barrier dysfunction, impaired innate immunity, and a Th2-dominant response mainly involving IL-4 and IL-13 [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30]. This evidence concerns the gene IL4 and Alzheimer disease.