CYP1B1 and Hypoplasia of the iris: Axenfeld–Rieger syndrome and primary congenital glaucoma share some causative genes (FOXC1 and CYP1B1) that may also induce other subtypes of ASD (aniridia, iris hypoplasia, and Peters anomaly), while the LTBP2 gene is confined to primary congenital glaucoma [10].