The observed spatial correlations between rT1/T2 maps and neurotransmitter receptor atlases in PSP and PSPS-II suggest that microstructural alterations in these chronic pain conditions may align with the spatial distribution of key neurochemical systems, including CB1, 5-HT1A/2A, mGluR5, and KappaOp receptors. This evidence concerns the gene GRM5 and supranuclear palsy, progressive, 1.