Increased circulating levels of C-reactive protein (CRP), periostin, inflammatory cytokines (IL-1, IL-6, IL-31, TSLP, among others), as well as Th2 skewing of peripheral T-cells, have been reported in EB subjects [239,242,243,244,245], implying a systemic inflammatory component. This evidence concerns the gene CRP and epidermolysis bullosa.