The most common PPOs and their respective prevalence among patients aged between 75 and 84 years old and among patients with ≥85 years old were the following: vitamin D supplements in the oldest that are housebound, experiencing falls, or with osteopenia (35.4% vs. 55.4%); vitamin D–calcium supplement in patients with osteoporosis and/or previous fragility fracture(s) (24.1% vs. 33.9%); and angiotensin-converting enzyme inhibitor with systolic heart failure and/or documented coronary artery disease (17.7% vs. 21.4%) (Table 4). This evidence concerns the gene ACE and Osteopenia.