The same trend was observed for PPOs between the two age groups studied here (vitamin D supplement in older people who are housebound or experiencing falls or with osteopenia; vitamin D and calcium supplement in patients with known osteoporosis and/or previous fragility fracture(s), and angiotensin-converting enzyme inhibitor with systolic heart failure and/or documented coronary artery disease). This evidence concerns the gene ACE and coronary artery disorder.