LRRK2 and Parkinson disease: Indeed, genetic ablation or pharmacological inhibition of LRRK2 protects nerve-like cells [29,33], HEK-293 cells [35], Drosophila melanogaster [27,100], human microglial cells [101], and rats [34] against rotenone, paraquat, trichloroethylene, tetrachloroethylene, manganese, and maneb-induced OS, apoptosis, and locomotor impairment as a model of PD.