Given that inhibition of LRRK2 kinase protects nerve-like differentiated cells from OS-induced cell death [33] and from PD-associated environmental toxicants [34], we theorized that specific inhibition of LRRK2 might protect PSEN1 mutant DALNs from Aβ-induced OS and apoptosis. Here, LRRK2 is linked to Parkinson disease.