MAPK1 and pachyonychia congenita: It promotes PC stemness by potentiating oncogenic signaling (integrin β5/pSrc/pSTAT3 signaling) [79], inhibits PC cell apoptosis via TNF-related apoptosis-inducing ligand [80], and is associated with invasion and adhesion of PC by promoting the expression of integrins, MMP-3, VEGF and activating Erk pathway [81].