HDAC2 and Alzheimer disease: In another study focusing on the unclear role of oxyresveratrol-β-cyclodextrin on cognition and histone deacetylase activity in AD, in silico docking and molecular dynamics simulation analysis indicated that oxyresveratrol potentially targets histone deacetylase-2 (HDAC2) and therefore, its in vivo ameliorative effect was evaluated in rats with experimental AD induced by intracerebroventricular injection of streptozocin (STZ) (3 mg/kg).