The utility of bioprinting and the specificity and biological influence of the ECM are evident in studies like the one of Kim et al. When comparing dECM and collagen as coatings for a PDMS chip to develop a multi-OoC system to study type 2 diabetes (T2D), their dECM successfully replicated T2D pathological conditions, downregulating pIRS-1, pAMPK, and GLUT-4 in adipose tissue, and GLUT-2 in the pancreas and liver, mirroring impaired glucose signaling seen in diabetes. The gene discussed is SLC2A2; the disease is type 2 diabetes mellitus.