Metabolic profile differences in AD demonstrated altered sulfur metabolism, with downregulation of cysteine, taurine, methionine, homocysteine, and DHPS, while sulfur containing B vitamins, biotin and pyridoxine, were increased in the AD cohort compared to HC (Figure 2 and Figure S2 for altered AD stool metabolic pathways). This evidence concerns the gene DHPS and Alzheimer disease.