It can be noted that, while diabetes-associated dyslipidemia results in the accumulation of incompletely oxidized lipid species, leading to impaired insulin action and glucose homeostasis, AX supplementation (concentrated from Plantago asiatica L.)decreased the concentrations of some metabolites (12α-hydroxylated bile acids, carnitines, free-fatty acids, and lysophophatidylcholine) associated with improved bile acid and lipid metabolism. The gene discussed is INS; the disease is diabetes mellitus.