In the letrozole-induced PCOS rat model, acetate (200 mg/kg, oral gavage, 21 days) addition reduced skeletal muscle malondialdehyde (MDA) levels, a marker of lipid peroxidation, while increasing glutathione (GSH) and nuclear factor erythroid 2-related factor 2 (Nrf2) levels as compared with the vehicle (water) group [42]. The gene discussed is NFE2L2; the disease is polycystic ovary syndrome.