INS and polycystic ovary syndrome: For instance, in a PCOS rat model, acetate (oral gavage, 200 mg/kg in water, for 21 days) treatment significantly decreases the levels of triglycerides (TG), total cholesterol (TC), and free fatty acids (FFA) in skeletal muscle as compared with vehicle group (water), suggesting that it can mitigate lipid accumulation and lipotoxicity in insulin-resistant skeletal muscle [42].