L-threonine (an amino acid) mitigates NP progression by (i) blocking nerve-injury-induced hippocampal TNFα overproduction in animals with chemotherapy-induced NP [56], (ii) enhancing glycinergic postsynaptic suppression of the motor reflex arc in the spinal cord of patients with multiple sclerosis [64], and (iii) changing amino acid metabolism in the brain of rats with diabetic neuropathic pain to decrease analgesic neurotransmitters [57]. Here, TNF is linked to multiple sclerosis.