There was a significant increase in the content of the protein AKT in the muscle tissue of the D-HIIT group rats compared to the non-diabetes groups (effect size = 0.57, p = 0.01, exercise effect), and there was no significant effect in rats treated with TRF compared to the non-TRF groups (effect size = 0.38, p = 0.05, TRF effect). The gene discussed is AKT1; the disease is diabetes mellitus.