NR1H4 and obesity due to melanocortin 4 receptor deficiency: Parabacteroides distasonis alleviates obesity-related metabolic dysregulation by producing succinate, which directly activates intestinal gluconeogenesis via fructose-1,6-bisphosphatase binding, paired with BA-mediated farnesoid X receptor (FXR) signaling to synergistically improve glucose and lipid homeostasis [60].