Dyshormonogenesis-associated congenital hypothyroidism is primarily caused by autosomal recessive mutations in genes, including TG, TPO, DUOX2, DUOXA2, SLC26A4 (Pendred), SLC5A5 (NIS), IYD, and SLC26A7,whereas monoallelic variants in DUOX2 and DUOXA2 have been frequently linked to transient CH (TCH) [4]. The gene discussed is DUOX2; the disease is congenital hypothyroidism.