ATP13A2 (PARK9) encodes for a neuronal lysosomal cation-transporting P-type ATPase and loss-of-function mutations of this gene cause diverse neurodegenerative disorders, including an autosomal recessive form of juvenile-onset parkinsonism with dementia (also known as Kufor-Rakeb syndrome) and early-onset PD. This evidence concerns the gene ATP13A2 and Kufor-Rakeb syndrome.