FBXO7 (PARK15) mutations are known to cause autosomal recessive juvenile- and early-onset PD with atypical pyramidal symptoms (Parkinsonian-pyramidal syndrome); the median age of onset of the phenotype associated with FBXO7 mutations is 17 years, but it can actually range from 10 to 52 years [84]. Here, FBXO7 is linked to parkinsonian-pyramidal syndrome.