Chen et al. demonstrated that PEG–PLE-coated C14-PEI micelleplexes, designed for the co-delivery of Cas9 mRNA and sgRNA, achieved a narrow size distribution (~140 nm, PDI = 0.08), reduced zeta potential, and up to 69% editing efficiency in KRAS-mutant lung cancer cells [34]. Here, KRAS is linked to lung cancer.