BAK1 and type 2 diabetes mellitus: In T2DM rats induced by high-fat diet (HFD) and streptozotocin (STZ), there was a significant reduction in the expression levels of the anti-apoptotic B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma-extra large (Bcl-xL) mRNA in the tibiae, accompanied by a significant increase in the expression levels of the pro-apoptotic Bcl-2-associated X (Bax) and Bcl-2 homologous antagonist/killer (Bak).