The positivity rate of PR(A+B) and PRB in the cervical epithelium exhibited a significant decrease during CIN2/3–CIS transition (from 29.7% to 8.8% and 29.7% to 15.7%, respectively) and further decreased to 4.1% and 7.7% in ICC, respectively (p < 0.001) (Table 1, Figure 2). This evidence concerns the gene RB1 and intrahepatic cholangiocarcinoma.