Our transcriptomic experiments detected NLRP3 activation only in U-2 OS cell line exposed to actinomycin D and nutlin-3a, which is consistent with the database presented by Fischer et al. [25] showing the activation of NLRP3 in U-2 OS cells exposed to nutlin-3a and in the NCI-H1299 p53-null lung cancer cell line with ectopically expressed p53. Here, TP53 is linked to lung cancer.