In a study published more recently, lipopolysaccharides from Klebsiella pneumoniae and other Enterobacteria were found to strongly inhibit the host p53 tumor suppressor pathway via a novel mechanism, namely by destabilizing TP53 mRNA through a TLR4-NF-κB-mediated inhibition of the RNA-binding factor Wig-1 [34]. The gene discussed is TP53; the disease is neoplasm.