First, to confirm the relevance of SPARC in hypertension and hypertension-related vascular injury, additional validation in alternative hypertensive animal models, such as spontaneously hypertensive rats (SHR), N-nitro-L-arginine methyl ester-induced hypertensive animals, and Dahl-salt sensitive hypertensive rats, is needed. The gene discussed is SPARC; the disease is hypertensive disorder.