The underlying type of genetic instability and the presence of DNA methylation in sporadic MSI CRCs suggest that this type of CRC originates from serrated polyps and is delineated by the CpG island methylator phenotype (CIMP) high status, methylation of MLHI, BRAF mutation, and MSI-H and is chromosomally stable. This evidence concerns the gene BRAF and colorectal carcinoma.