Studies have revealed that IL-8 (also known as CXCL8)/CXC chemokine receptor 1 and 2 (CXCR1/2, also known as IL8R1/2) signaling contributes to tumor cell proliferation, invasion, and neovascularization of glioblastoma [28]. This evidence concerns the gene CXCL8 and glioblastoma.