In this mouse model, the authors found that the retroviral vector expressing PDGFB primarily drives the development of glioblastoma, which consistently expresses nestin protein, a well-known biomarker for neuroglial progenitor cells, indicating that activation of PDGFB signaling may be an initial or early event in neuro-oncogenesis. The gene discussed is PDGFB; the disease is glioblastoma.