IL-8 and/or GROα bind to CXCR1, eventually promoting glioblastoma proliferation via the ERK1/2 pathway that can be blocked by CXCR1 siRNA (Figure 4J,K), suggesting that the activation of the proliferative ERK1/2 pathway in glioblastoma is, at least in part, CXCR1-dependent. The gene discussed is MAPK3; the disease is glioblastoma.