Although this is the first report regarding the critical role of DNA-PK/MYT1L in the proliferative IL-8/GROα-CXCR1 signaling loop in glioblastoma, the significant contributing role of IL-8-CXCR1/2 axes in the proliferation and angiogenesis of glioblastoma cells has been demonstrated before [28]. Here, CXCL8 is linked to glioblastoma.