CXCL8 and neoplasm: Immunohistochemical staining has indicated the expression of IL-8 in 66.7–67.3% of WHO grade IV glioblastoma tissues, with the expression of its receptor CXCR1 found primarily in both tumor-associated vessels and grade IV glioblastomas [28], supporting the previous report showing a crucial role of IL-8/CXCR1/2 signaling in glioblastoma stem cells [58].