The authors examined the effect of recombinant high-mobility group box 1 (rHMB1) through receptors for advanced glycation end products (RAGE) on cell migration in human breast cancer cell lines, concluding that after down-regulating AKT, the subsequent PI3K inhibition dephosphorylated AKT, and prevented PD-L1 expression [159]. The gene discussed is PIK3CA; the disease is breast cancer.