NFATC2 and colorectal cancer: In fact, ASICs’ acidic activation in ovarian tissue could induce a remodeling of the cellular homeostasis as proved in colorectal cancer-cell studies, where the up-regulation of the ASIC2 significantly enhanced cell proliferation via the calcineurin/NFAT1 signaling pathway, while ASIC2 knockdown had the reverse effect [53,54].