These include deficiencies in the cellular membrane, for example cystic fibroses transmembrane conductance regulator (CFTR) [26], and in other cellular organelle membranes, for example Lamin A deficiency in the nucleus envelope seen in Progeria (Hutchinson-Gilford Progeria Syndrome) [27], and SEC61 translocon deficiency [28] in the ER membrane. This evidence concerns the gene CFTR and Hutchinson-Gilford progeria syndrome.