NOS3 and hypertensive disorder: Liang et al. [28] observed that magnolol (100 mg/kg/day, for 3 weeks) modulated insulin-induced aortic vasodilation to delay the development of hypertension by restoring insulin-induced protein kinase B (also known as AKT) and endothelial nitric oxide synthase (eNOS) activation, decreasing tribbles 3, and increasing PPARγ in young spontaneously hypertensive rats.