Certain tumor types, including renal cell carcinoma, pancreatic neuroendocrine tumors, and hepatocellular carcinoma, have been shown to enhance systemic CRP levels indirectly, through tumor-derived production of pro-inflammatory cytokines such as interleukin-6 (IL-6), which in turn stimulates hepatic CRP synthesis [28]. The gene discussed is IL6; the disease is renal cell carcinoma.