Several EMT transfection factors including Snail 1, Snail 2 (Slug), Twist1, Twist2, ZEB1, ZEB2, PRRX1, GOOSECOID (GSC), E47 (helix loop transcription factor), FOXC2 (Forkhead X box protein P2), SOX4, (SRY box transcription factor 4), SOX9 (SRY box transcription factor 9), HAND1 (heart and neural crest derivatives expressed 1), and HAND2 (heart and neural crest derivatives expressed 2), promote mesenchymal properties in epithelial tumor cells. Here, HAND1 is linked to neoplasm.