Canonical Wnt/β-catenin pathway activity is regulated by targeting β-catenin into a multi-protein complex formed by the tumor suppressors Axin, APC (Adenomatous Polyposis Coli) and GSK3β, the latter ultimately phosphorylating β-catenin and targeting it for ubiquitination and subsequent proteasomal degradation [19]. The gene discussed is APC; the disease is neoplasm.