Based on our analysis, the upstream regulators MEF2C, KDM5A, and NR5A2, along with the downregulation of their target genes (Ccl9, COL10A1, CXCL2, MMP8, Ccl7, IL1B, IL6, SOD2, and others), may represent an additional mechanism by which Fer-1 exerts its therapeutic effects in AD. Here, NR5A2 is linked to Alzheimer disease.