A connection between TPPP3, DEFA3, and HLA-DRB5, as evidenced by the clustering observed in the current analysis (Figure 3), had not yet been described, and if it presents as a distinguishing signaling axis between men and women with GBM, this merits additional investigation as it links the epithelial–mesenchymal transition to tumor grade and prognosis and the innate immune system, with a clear link to biological sex in the GBM tissue proteome. Here, DEFA3 is linked to neoplasm.