CD44 and central nervous system cancer: The current study illustrates potential relationships between well-known glioma drivers in males compared to females in GBM, some of which are better understood and studied; for example, the relationship between EGFR, BCOR, and FAT4 and connections to CD44 but with potential signaling via sex-related proteins such as HCG, as well as potential metabolic programming that may drive tumor behavior, e.g., via KLK3 (BPSA) and IGFBP1, which can connect to BCOR (Figure 7).