IGHE and central nervous system cancer: In contrast, others are already associated with glioma (TPSNR (HLA1 antigen processing protein) [37], IgE [38], SAA1 (potential prognostic marker) [39], NCAN (also known as CSPG3, glycosylated chondroitin sulfate proteoglycan implicated in the tumor microenvironment) [40], and SPIT3 [41], and, in our analysis, are also associated with biological sex (Figure 6).