Antiproliferative activity against ovarian cancer cell line A2780IC50 5.9 μM for 68; IC50 9.4 μM for 69Could inhibit cell metastasis and invasion through damage of actin dynamics and downregulation of MMP2/MMP9 proteins. Mitochondrial accumulation of metal-arene complexes caused mitochondrial membrane potential damage, oxidative phosphorylation, ATP depletion, and autophagy. Displayed excellent activity to disintegrate 3D multicellular tumor spheroids, showing potential for the treatment of solid tumors. This evidence concerns the gene MMP2 and neoplasm.