Antiproliferative activity against human cancer cell lines SMMC-7721 (IC50 5.57 μM), HepG2 (IC50 7.49 μM), MNK-45 (IC50 6.31 μM), SW620 (IC50 6.00 μM), and A549 (IC50 5.79 μM)Induced cell apoptosis and autophagy in SMMC cells, resulting in antiproliferation and G0/G1 cell cycle arrest by regulating protein expression levels of Bax, Bcl-2, and LC3. The gene discussed is MAP1LC3A; the disease is cancer.