MMP2 and ovarian cancer: Antiproliferative activity against ovarian cancer cell line A2780IC50 5.9 μM for 68; IC50 9.4 μM for 69Could inhibit cell metastasis and invasion through damage of actin dynamics and downregulation of MMP2/MMP9 proteins. Mitochondrial accumulation of metal-arene complexes caused mitochondrial membrane potential damage, oxidative phosphorylation, ATP depletion, and autophagy. Displayed excellent activity to disintegrate 3D multicellular tumor spheroids, showing potential for the treatment of solid tumors.